
We are entering an incredibly exciting scientific era with rapidly advance of sequencing technologies, and exponential accumulation of omics data such as genomic, transcriptomic and epigenomic data. Especially, advances of sequencing technologies have scaled-down the amount of DNA necessary for library preparation to the level that DNA/RNA in a single cell suffices for sequencing. Single cell sequencing has the potential to revolutionize our understanding of many fundamental questions in multiple disciplines such as developmental biology, stem cell biology, cell fate decision, immunity and metagenomics. The development of single cell sequencing also has a lot clinical implication. For example, the widespread cellular heterogeneity in clinical samples could result in selective drug resistance and failure of treatment in during cancer treatment. Single cell sequencing is ideally powerful for identifying variations in heterogeneous samples and is critical for the success of precision medicine. However, it is still a big challenge for scientists to gain the biological insights from the huge amount of single cell multi-omics data.
Dr. Jin’s lab is interested in identifying genetic/epigenetic changes underlying cancer, and developing disease risk prediction model for precision medicine. The long-term goal of the lab is to develop efficient personalized treatment for cancers based on patients’ genetic background. In near future, the lab will focus on investigating genetic/epigenetic heterogeneity and micro-evolution of cancer cells using single cell sequencing related technologies.
Congratulations to Wenfei for the Trac-looping paper on Nature methods, in which he is a co-first author. In this paper, a new approach for detecting long-distance gene regulation was developed.
Lai B#, Tang Q#, Jin W#, Hu G#, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 PMID: 30150754 (#equal contribution) Abstract: Long-range chromatin...
CTCF paper has been published on Molecular Cell, in which Wenfei is a co-first author with SUSTech as present address.
Ren G#, Jin W#, Cui K#, Rodrigez J, Hu G, Zhang Z, Larson D, Zhao K. 2017 CTCF-mediated enhancer-promoter interaction is a critical regulator of cell-to-cell variation of gene expression. Mol Cell. 67:1049–1058 This study provides many new insights on the the function...
Congratulations to Zhijun, for his Abstract been selected for Oral Presentation at The 5th International Symposium of Genetics/The 2nd International Epigenomics Conference (Only 6 Young Scholars were selected for Oral Presentation in this conference).
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bPPI-seq has been published on Cell Research.
Zhang Y, Ku WL, Liu S, Cui K, Jin W, Tang Q, Lu W, Ni B, Zhao K. 2017 Genome-wide identification of histone H2A and histone variant H2A.Z-interacting proteins by bPPI-seq. Cell Res....
Congratulations to Pengfei, for him being selected to the Shenzhen Talent program (Peacock Plan).
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The single cell precision medicine Lab website was launched. Thanks Pengfei and Xuefei’s effort.
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We are recently hiring postdoctoral fellows and research assistants, feel free to contact us :)